Dr. De Melo (He/Him) joined the School of Nursing in July 2022 as an assistant professor, returning to the program after previously serving as a teaching assistant during his doctoral studies.
Dr. De Melo’s career has provided him with extensive teaching, research and writing experiences. His graduate studies focused on protein-protein interactions and the regulation of the tumoursurpressor PTEN. After obtaining his Ph.D. from McMaster in 2014, he continued his training at the Princess Margaret Cancer Centre as a postdoctoral fellow, where his research focused on the post-translational regulation of the MYC protein. During this time he developed and taught a laboratory course on CRISPR gene editing, taught research methodology in the Faculty of Medicine at the Univeristy of Toronto and lead the development of a new training program for graduate students and postdoctoral fellows at UHN. Before joining the faculty in the School of Nursing, Dr. De Melo was a medical copywriter at Klick Health where he helped develop educational content on clinical trials and newly approved therapueutics for health care professionals.
De Melo, J., Kim, S. S., Lourenco, C., & Penn, L. Z. (2017). Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism. Oncogene, 36(49), 6815–6822. https://doi.org/10.1038/onc.2017.268
Kalkat, M., De Melo, J., Hickman, K. A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W. B., & Penn, L. Z. (2017). MYC deregulation in primary human cancers. In Genes (Vol. 8, Issue 6, pp. 2–30). https://doi.org/10.3390/genes8060151
McCurdy, T., Volterman, K., Shiell, R., Zeadin, M., Dunn, K., De Melo, J., & Helli, P. (2017). Enhancing Two-stage Collaborative Exams by Incorporating Immediate Feedback. WCSE Proceedings, 1(1), Article 9. http://ir.lib.uwo.ca/wcsedust/vol1/iss1/9
De Melo, J., & Tang, D. (2015). Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk. PLOS ONE, 10(5), e0127546. https://doi.org/10.1371/journal.pone.0127546
De Melo, J., Lin, X., He, L., Wei, F., Major, P., & Tang, D. (2014). SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN. Cellular Signalling, 26(12), 2749–2756. https://doi.org/10.1016/j.cellsig.2014.08.013
A full list of publications can be found on Google Scholar