Bio
Dr. De Melo (He/Him) joined the School of Nursing in July 2022 as an assistant professor, returning to the program after previously serving as a teaching assistant during his doctoral studies.
Dr. De Melo’s career has provided him with extensive teaching, research and writing experiences. His graduate studies focused on protein-protein interactions and the regulation of the tumoursurpressor PTEN. After obtaining his Ph.D. from McMaster in 2014, he continued his training at the Princess Margaret Cancer Centre as a postdoctoral fellow, where his research focused on the post-translational regulation of the MYC protein. During this time he developed and taught a laboratory course on CRISPR gene editing, taught research methodology in the Faculty of Medicine at the Univeristy of Toronto and lead the development of a new training program for graduate students and postdoctoral fellows at UHN. Before joining the faculty in the School of Nursing, Dr. De Melo was a medical copywriter at Klick Health where he helped develop educational content on clinical trials and newly approved therapueutics for health care professionals.
Select Publications
De Melo, J., Kim, S. S., Lourenco, C., & Penn, L. Z. (2017). Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism. Oncogene, 36(49), 6815–6822. https://doi.org/10.1038/onc.2017.268
Kalkat, M., De Melo, J., Hickman, K. A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W. B., & Penn, L. Z. (2017). MYC deregulation in primary human cancers. In Genes (Vol. 8, Issue 6, pp. 2–30). https://doi.org/10.3390/genes8060151
McCurdy, T., Volterman, K., Shiell, R., Zeadin, M., Dunn, K., De Melo, J., & Helli, P. (2017). Enhancing Two-stage Collaborative Exams by Incorporating Immediate Feedback. WCSE Proceedings, 1(1), Article 9. http://ir.lib.uwo.ca/wcsedust/vol1/iss1/9
De Melo, J., & Tang, D. (2015). Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk. PLOS ONE, 10(5), e0127546. https://doi.org/10.1371/journal.pone.0127546
De Melo, J., Lin, X., He, L., Wei, F., Major, P., & Tang, D. (2014). SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN. Cellular Signalling, 26(12), 2749–2756. https://doi.org/10.1016/j.cellsig.2014.08.013
A full list of publications can be found on Google Scholar